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Precision Medicine for Your Practice: Genetic Testing in Pediatric Neurology - CNE is a Course

Precision Medicine for Your Practice: Genetic Testing in Pediatric Neurology - CNE

Self-paced
0.5 credits

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Full course description

About this Course

Pediatric neurology providers and patients have more options than ever before for genetic testing. Evidence is growing for the utility of genetic testing for a range of conditions for the purpose of diagnosis and optimizing treatment. While genetic testing can be a powerful tool in certain situations, not all genetic testing is the same. Broader tests assess more genes and increase the possibility of a diagnosis, but also confer specific benefits, limitations, and challenges in results interpretation and counseling.

Precision Medicine for Your Practice is a series of short (20-30 min), online modules covering specific topics in genomics and precision medicine. In this module, Genetic Testing in Pediatric Neurology, participants will learn the benefits and limitations of genetic testing for pediatric neurological conditions. This online module will include five parts: overview information via an animated video; practice cases to facilitate learning-by-doing; and "dig deeper," logistics, and additional resources for those who are interested in more detail.

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CNE Disclosures

Activity Overview

Precision Medicine For Your Practice: Genetic Testing in Pediatric Neurology
Original Publication Date: September 5, 2019
Expiration Date: September 21, 2020 

Objectives
Upon completion of this educational activity, the physician will be able to:

  • Identify scenarios in which there is further value added by molecular diagnosis
  • Evaluate the appropriateness of different genetic tests for clinical context

Target Audience
This activity is designed to meet the educational needs of practicing advanced practice nurses, physicians and physician assistants who work with children with neurologic conditions.

CNE Approval Statement
The Jackson Laboratory is co-providing this continuing nursing education activity with the American Medical Association and Scripps Translational Science Institute. This continuing nursing education activity was approved by the Northeast Multi-State Division (NE-MSD), an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation.

Claiming Your Credit
In order to claim credit 1) answer the pre-assessment questions, 2) work through the module content in its entirety, 3) successfully complete the post-assessment answering 4 out of 5 questions correctly and 4) complete the evaluation. Nurses are eligible for a maximum of .50 contact hours upon the completion of this activity.


Planning Committee

  • Emily Edelman, MS, CGC, Associate Director, Clinical and Continuing Education, The Jackson Laboratory
  • Kate Reed, MPH, ScM, CGC, Director, Clinical and Continuing Education, The Jackson Laboratory
  • Therese Ingram Nissen, MA, Senior Instructional Designer/Technologist, The Jackson Laboratory
  • Sean C. McConnell, PhD, Senior Policy Analyst, Science, Medicine & Public Health, CME Program Committee, AMA
  • Laura Nicholson, MD, PhD, Director of Education, Scripps Research Translational Institute
  • Janet K. Williams, PhD, RN, FAAN, University of Iowa, Professor of Nursing, Chair of Behavioral and Social Science Research, University of Iowa

Faculty

  • Kate Reed, MPH, ScM, CGC, Director, Clinical and Continuing Education, The Jackson Laboratory (Author)
  • Emily Edelman, MS, CGC, Associate Director, Clinical and Continuing Education, The Jackson Laboratory (Author)
  • Therese Ingram Nissen, MA, Senior Instructional Designer/Technologist, The Jackson Laboratory (Author)
  • Linda Steinmark, MS, LCGC, Project Manager, The Jackson Laboratory (Author)
  • Sean C. McConnell, PhD, Senior Policy Analyst, Science, Medicine & Public Health, CME Program Committee, AMA (Author)
  • Laura Nicholson, MD, PhD, Director of Education, Scripps Research Translational Institute (Author)

Subject Matter Experts

  • Nicolas Abreu, MD, Post-Graduate Fellow Neurodevelopmental Disabilities, Boston Children’s Hospital (Content Reviewer)
  • Katie Braverman, MS, CGC, Genetic Counselor Coordinator, Kaiser Permanente (Content Reviewer)
  • Kim Glaser, MS, CGC, Genetic Counselor, Joe DiMaggio Children’s Hospital (Content Reviewer)
  • Barbara Hallinan, MD, PhD, Child Neurologist, Cincinnati Children’s Hospital (Content Reviewer)
  • Weiyi Mu, ScM, CGC, Genetic Counselor, Johns Hopkins University (Content Reviewer)
  • Cecilia Rajakaruna, MS, CGC, Genetic Counselor, Cincinnati Children’s Hospital (Content Reviewer)
  • Beth Sheidley, MS, CGC, Senior Genetic Counselor Program Manager, Boston Children’s Hospital (Content Reviewer)
  • Marissa Vawter, MD, Assistant Professor of Child Neurology, Cincinnati Children’s Hospital (Content Reviewer)

Conflict of Interest Disclosure
Unless otherwise noted, the program planners and faculty do not have a financial interest/arrangement or affiliation with any organizations that could be perceived as a real or apparent conflict of interest in the context of the subject of this course.

The following disclosures are reported that could be perceived as a real or apparent conflict of interest in the education program:

Janet K. Williams, PhD, RN, FAAN, stockholder of Pfizer

In her role as a planner, Dr. Williams recused herself from all deliberations relating to content related to the commercial entities with which she has a financial interest and is not responsible for reviewing for bias any related content. All educational material has been peer-reviewed by external reviewers to assess for bias.

References

Baker E, Jeste S. Diagnosis and Management of Autism Spectrum Disorder in the Era of Genomics Rare Disorders Can Pave the Way for Targeted Treatments. Pediatr Clin North Am. 2015;62:607-618.

Bello L, Pegoraro E. Genetic diagnosis as a tool for personalized treatment of Duchenne muscular dystrophy. Acta Myol. 2016;35(3):122-127.

Bird TD. Approaches to the Patient with Neurogenetic Disease. Clin Lab Med. 2010;30:785-793.

Demarest ST, Brooks-Kayal A. From molecules to medicines: the dawn of targeted therapies for genetic epilepsies. Nat Rev Neurol. 2018;14(12):735-745.

Dowling JJ, D Gonorazky H, Cohn RD, Campbell C. Treating pediatric neuromuscular disorders: The future is now. Am J Med Genet A. 2018;176(4):804-841.

Fogel BL. Genetic and genomic testing for neurologic disease in clinical practice. Handb Clin Neurol. 2018;147:11-22.

Fogel BL, Saty Satya-Murti, Cohen BH. Clinical exome sequencing in neurologic disease. Neurol Clin Pr. 2016;6:164-176.

Huang Y, Yu S, Wu Z TB. Genetics of hereditary neurological disorders in children. Transl Pediatr. 2014;3(2):108-119.

Kang PB. Ethical issues in neurogenetic disorders. Ethical Leg Issues Neurol. 2013;118:265-276.

Kaufmann WE. Neurogenetics in Child Neurology: Redefining a Discipline in the Twenty-first Century. Curr Neurol Neurosci Rep. 2016;16:103.

Kiely B, Vettam S, Adesman A. Utilization of genetic testing among children with developmental disabilities in the United States. Appl Clin Genet. 2016;9:93-100.

Narayanan V. Genetics and Child Neurology: What Every Trainee/Resident Should Know. Semin Pediatr Neurol. 2011;18:81-84.

Neubauer BA, Lemke JR. From Genetics to Genomics: A Short Introduction for Pediatric Neurologists. Neuropediatrics. 2016;47:5-11.

Ream MA, Patel AD. Obtaining genetic testing in pediatric epilepsy. Epilepsia. 2015;56(10):1505-1514.

Silveira-Moriyama L, Paciorkowski AR. Genetic Diagnostics for Neurologists. Contin Lifelong Learn Neurol. 2018;24(1):18-36.

Sisodiya SM. Genetic screening and diagnosis in epilepsy? Curr Opin Neurol. 2015;28(2):136-142.

Tarailo-Graovac M, Shyr C, Ross CJ, et al. Exome Sequencing and the Management of Neurometabolic Disorders. N Engl J Med. 2016;374:2246-2255.

Vento JM. Family History: A Guide for Neurologists in the Age of Genomic Medicine. Semin Pediatr Neurol. 2012;19:160-166.

Hardware/software Requirements
Audio speakers or headphones
Screen resolution of 800X600 or higher
Adobe Reader 5.0 or higher 

For best performance in a mobile environment, please download the Canvas Mobile App for IOS and Android.

Check the basic computer specifications and supported browsers.

Should you have technical questions or questions regarding the content of the activity, please email Clinical and Continuing Education at the Jackson Laboratory.

Disclaimer 
All information in Precision Medicine for Your Practice is provided for educational purposes only. This information is not a substitute for clinical guidance or the consultation of a medical professional. Always seek the advice of a qualified health professional with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in Precision Medicine for Your Practice. Reliance on any information in Precision Medicine for Your Practice is solely at your own risk. The Jackson Laboratory does not endorse or recommend any specific procedures, tests, products, services, health professionals or other information that may be found in Precision Medicine for Your Practice.

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