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Precision Medicine for Your Practice: Exploring Pharmacogenomic Testing (CME) is a Course

Precision Medicine for Your Practice: Exploring Pharmacogenomic Testing (CME)

Started May 20, 2021
0.5 credits


Full course description

About this course

Pharmacogenomic testing can provide clinical information about how specific variants may impact therapeutic efficacy and toxicity, as well as how to select the most appropriate drug, the optimal dose, and how to identify patients at risk for more frequent adverse drug reactions.

Precision Medicine for Your Practice is a series of short (30 min), online modules covering specific topics in genomics and precision medicine. In this module, Exploring Pharmacogenomic Testing, participants will learn about the benefits and limitations of pharmacogenomic testing, how to determine whether pharmacogenomic testing is appropriate for the patient and the application of test results to patient management. There are five parts of the module: overview via an animated video; practice cases to facilitate learning-by-doing; "dig deeper" for more in-depth topics; and logistics and additional resources for more detail.

Already enrolled? Access the course here.


Activity Overview

Precision Medicine for Your Practice: Exploring Pharmacogenomic Testing - CME

Original Publication Date: May 20, 2021
Expiration Date: May 20, 2024


Upon completion of this educational activity, the learner will be able to:

  • Determine whether pharmacogenomic testing is appropriate for the patient
  • Apply pharmacogenomic testing results to patient management

Target audience

This activity is designed to meet the educational needs of clinicians who are using or interested in using pharmacogenomic information to help make decisions about drug selection and dosing.

Accreditation Statement

The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation Statement

The American Medical Association designates this enduring material for a maximum of .50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Claiming Your CME Credit

In order to claim AMA PRA Category 1 Credit™, you must: 1) answer the pre-assessment questions, 2) work through the module in its entirety, 3) successfully complete the post-assessment by answering 4 out of 5 questions correctly and 4) complete the evaluation.

Multimedia Contributors

  • Amy B. Cadwallader, PhD, Director, Science and Drug Policy, Science, Medicine & Public Health, American Medical Association
  • Emily Edelman, MS, CGC, Associate Director, Clinical and Continuing Education, The Jackson Laboratory
  • Therese Ingram Nissen, MA, Senior Instructional Designer/Technologist, The Jackson Laboratory
  • Sean C. McConnell, PhD, Senior Policy Analyst, Science, Medicine & Public Health, CME Program Committee, American Medical Association
  • Laura Nicholson, MD, PhD, Director of Research, Graduate Medical Education, Scripps Health
  • Kate Reed, MPH, ScM, CGC, Director, Clinical and Continuing Education, The Jackson Laboratory
  • Karen Reinbold, MBA, Health and Science Director, American Medical Association
  • Linda Steinmark, MS, CGC, Project Manager, Clinical and Continuing Education, The Jackson Laboratory

Disclosure Statement

Unless noted, all individuals in control of content reported no relevant financial relationships. 


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Association for Molecular Pathology Position Statement. Best Practices for Clinical Pharmacogenomic Testing. 2019 Sept 4.

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Borden BA, Lee SM, Danahey K, et al. Patient-provider communications about pharmacogenomic results increase patient recall of medication changes. Pharmacogenomics J. 2019; 19(6):528-537.

Caraballo PJ, Hodge LS, Bielinski SJ, et al. Multidisciplinary model to implement pharmacogenomics at the point of care. Genet Med. 2017; 19(4):421-429.

Carere DA, VanderWeele TJ, Vassy JL, et al. Prescription medication changes following direct-to-consumer personal genomic testing: findings from the Impact of Personal Genomics (PGen) Study. Genet Med. 2017; 19(5):537-545.

Cavallari LH, Van Driest SL, Prows CA, et al. Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing. Genet Med. 2019; 21(10):2255-2263.

Chanfreau-Coffinier C, Hull LE, Lynch JA, et al. Projected Prevalence of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among US Veterans Health Administration Pharmacy Users. JAMA Netw Open. 2019; 2(6):e195345.

Crews KR, Gaedigk A, Dunnenberger HM et al. Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update. Clin Pharmacol Ther. 2014; 95(4):376-382.

Gaedigk A, Sangkuhl K, Whirl-Carrillo M, Klein T, Leeder JS. Prediction of CYP2D6 phenotype from genotype across world populations. Genet Med. 2017; 19: 69-76.

Haga SB. Pharmacogenomic Testing In Pediatrics: Navigating The Ethical, Social, And Legal Challenges. Pharmacogenomics Pers Med. 2019; 12:273–285.

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Hicks JK, Dunnenberger HM, Gumpper KF, Haidar CE, Hoffman JM. Integrating pharmacogenomics into electronic health records with clinical decision support. Am J Health Syst Pharm. 2016; 73:1967–76.

Hippman C, Nislow C. Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good. J Pers Med. 2019; 9(3).

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Lemke AA, Hulick PJ, Wake DT, et al. Patient perspectives following pharmacogenomics results disclosure in an integrated health system. Pharmacogenomics. 2018; 19(4):321-331.

Malki MA, Pearson ER. Drug–drug–gene interactions and adverse drug reactions. Pharmacogenomics J. 2020; 20:355-366.

Mukerjee G, Huston A, Kabakchiev B, Piquette-Miller M, van Schaik R, Dorfman R. User considerations in assessing pharmacogenomic tests and their clinical support tools. NPJ Genom Med. 2018; 3:26.

Patel JN, Wiebe LA, Dunnenberger HM, McLeod HL. Value of Supportive Care Pharmacogenomics in Oncology Practice. Oncologist. 2018; 23(8):956-964.

Patient-Centered Primary Care Collaborative. The Patient-centered Medical Home: Integrating Comprehensive Medication Management to Optimize Patient Outcomes Resource Guide, Second Edition. June 2012, accessed September 2020 from

Pratt VM, Cavallari LH, Del Tredici AL, et al. Recommendations for Clinical CYP2C9 Genotyping Allele Selection: A Joint Recommendation of the Association for Molecular Pathology and College of American Pathologists. J Mol Diagn. 2019; 21(5):746-755.

Reisberg S, Krebs K, Lepamets M. Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions. Genet Med. 2019; 21(6):1345-1354.

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van der Wouden CH, van Rhenen MH, Jama WOM, et al. Development of the PGx-Passport: A Panel of Actionable Germline Genetic Variants for Pre-Emptive Pharmacogenetic Testing. Clin Pharmacol Ther. 2019; 106(4):866-873.

Wang L, McLeod HL, Weinshilboum RM. Genomics and drug response. N Engl J Med. 2011; 364(12):1144-53.

Weitzel KW, Duong BQ, Arwood MJ, et al. A stepwise approach to implementing pharmacogenetic testing in the primary care setting. Pharmacogenomics. 2019; 20(15):1103-1112.

Hardware/Software Requirements

Audio speakers or headphones
Screen resolution of 800X600 or higher
Adobe Reader 5.0 or higher 

For best performance in a mobile environment, please download the Canvas Mobile App for IOS and Android.

Check the basic computer specifications and supported browsers.

Should you have technical questions or questions regarding the content of the activity, please email Clinical and Continuing Education at the Jackson Laboratory.


All information in Precision Medicine for Your Practice is provided for educational purposes only. This information is not a substitute for clinical guidance or the consultation of a medical professional. Always seek the advice of a qualified health professional with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in Precision Medicine for Your Practice. Reliance on any information in Precision Medicine for Your Practice is solely at your own risk. The Jackson Laboratory does not endorse or recommend any specific procedures, tests, products, services, health professionals or other information that may be found in Precision Medicine for Your Practice.


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